N,N-Dimethylglycine (short: DMG) is an intermediate of choline metabolism. Betaine (metabolized from choline and is a metabolic precursor to dimethylglycine) donates a methyl group to homocysteine to form methionine [1]. By this removal of one methyl group from betaine, dimethylglycine is formed [1]. DMG is often sold commercially as hydrochloride salt (dimethylglycine HCL).
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Dimethylglycine’s Effects on Athletic Performance
Dimethylglycine DMG is a derivative of the amino acid glycine and is found naturally in foods such as beans, cereal grains, and liver. It is also manufactured in the body during the metabolism of choline. The use of DMG to treat autism is controversial, and current research shows mixed results. DIMETILGLICINA, AUTISMO. E LINGUAGGIO. Mac memory cleaner. Da oltre 25 anni l'A.R.I. Raccoglie le testimonianze di genitori che hanno provato la DMG sui loro bambini autistici. Effetti notevoli sono stati osservati in numerosi casi, specialmente riguardo il miglioramento del linguaggio. In alcuni casi farmaco-resistenti si sono avute risposte positive alla DMG.
Dimethylglycine has been claimed to be an athletic performance enhancer and can be found in various sports supplements. Since dimethylglycine donates methyl groups to transmethylation process it is claimed to improved energy usage. Therefore, it is often marketed and sold as an energiser.
When dimethylglycine was first discovered in Russia, it was known as vitamin B-15. Researchers synthesized DMG as a way to reverse the effects of aging in cosmonauts: cosmonauts sent into space were exposed to high levels of ionizing radiation. After using DMG prior to space travel, cosmonauts reportedly displayed no aging effects. It can also be used to improve speech and behavior in autism. Sahelian calls DMG an anti-stress supplement that may have anti-aging effects, ” Read more here What is TMG? TMG is an important cofactor in methylation, a process that occurs in every cell of mammals to synthesize and donate methyl groups (CH 3 ) for other processes in the body.
The interest in dimethylglycine arose from a report indicating that N,N-Dimethylglycine reduces lactic acid concentration in blood in response to surgical stress in animals [2]. Further human and animal studies yielded inconsistent results. A study on dimethylglycine-treated horses by Moffit et al. [3] reported lower plasma lactate concentrations after treadmill exercise. However, this study raised doubts about dimethylglycines effectiveness due to an unbalanced design used. Rose et al. [4] found no differences in muscle lactate concentrations in horses treated with dimethylglycine and horses receiving placebo.
Dmg Dimethylglycine Benefits
In trained athletes, Pipes [5] noted a 23,6% increase in time to fatigue after DMG supplementation. In contrast, Gray and Larry [6] reported no significant changes in short-term maximal treadmill performance between the group receiving pangamic acid (calcium gluconate and N, N-Dimethylglycine) and control. No improvements in aerobic and anaerobic performance were also reported when 400 mg of DMG per/kg of body weight was administered to elite basketball players [7]. DMG also failed to improve maximal treadmill exercise to exhaustion in well-trained college women [8]. Authors of this study concluded that there is no evidence to recommend DMG as an ergogenic aid to endurance athletes.
Dimethylglycine supplementation seems to have little to no effect on athletic performance besides evidence available is limited and conflicting. More well-researched clinical trials should be done before any definitive conclusions can be made.
Other Dimethylglycine UsesTreatment of Autism
N,N-dimethylglycine has also been reported to be beneficial in children with autism [9]. Kern et al. [9] reported that some children seem to respond positively to the dimethylglycine supplementation but overall behavioural assessments were not significantly different from children receiving placebo. Same was reported by Bolman and assistants [10], however, the weakness of this study is low dosage used in a small number of children. According to available evidence, subjects treated with DMG show little to no difference compared to untreated subjects for treatment of autism spectrum disorder [11].
Dimethylglycine AutismImmunostimulant Properties
DMG may improve body’s immune system as reported by Graber and others [12]. Results of their study suggest that dimethylglycine supplementation improves humoral as well as cell-mediated immune responses in humans [12].
Side Effects
Very large doses up to 200 mg/kg given to animal models caused no adverse events [7]. Download google chrome on mac. This is not surprising as DMG is a natural metabolite which doesn’t build up in the body.
(Other common names: Pangamic Acid, Vitamin B15, Pangamate)
References
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